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Typeface
First, choose a typeface that appeals to you. Make sure it is appropriate to both the reader and the book. Typefaces have personalities, and different designs will appeal to people of different ages. If your reader is either very young or a senior, then choose a simple, well-designed typeface in a large size. The reader should be able to read the typeface without strain. Typefaces that are more basic are more legible than typefaces that have been embellished, abstracted, or condensed (squeezed). A serif font (such as Times, Garamond, or New Century Schoolbook), is much more legible than a sans-serif font (such as Helvetica). Use a serif font for the body text. A bold serif or sans serif font is appropriate for titles and subtitles. The typical text size is 10, 11 or 12 point.
Word Spacing
Proper word spacing creates greater legibility and is also more pleasing aesthetically. Make sure there is neither too much space nor too little space between words. Too much space creates vertical "rivers of white" coursing through the pages, and is often seen in newspapers where columns are very narrow.
Length of Line (Column Width)
Reading many long lines of type causes fatigue. Too short a line breaks up words or phrases that are generally read as a unit. The length of line depends on the size of the type. A good rule of thumb is to set a line about 65 characters long.
Leading
Leading is the space between lines of type. Your choice of typeface, type size, word spacing and length of line all affect the amount of leading you will need. Some visual judgement comes into play.
Alignment
Most books are set justified because it is best suited for sustained reading comfort.
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